Nā ʻike hou i ka Pūnaehana Killer Natural o ka Hana Anti-Cancer

Ua hoʻolaha ʻo Oncolytics Biotech® Inc. i kēia lā i ka hoʻolaha ʻana i ka ʻikepili preclinical a me ka ʻikepili maʻi ma ka pelareorep i loko o ka puke pai loiloi ʻia ʻo Immunology. ʻO ka pepa, i kapa ʻia ʻo "Oncolytic virus treatment differentially affects the CD56dim and CD56bright NK cell subsets in vivo and regulates a spectrum of human NK cell activity," i paʻi ʻia me ka hui pū ʻana me nā mea noiʻi ma kekahi mau keʻena hanohano, me ka University of Leeds School of Medicine a ka Institute of Cancer Research, Lādana. Hiki ke loaʻa kahi loulou i ka pepa ma ke kaomi ʻana ma aneʻi.

Hōʻike ʻia i loko o ka pepa nā haʻawina in vitro e loiloi ana i nā hopena o ka pelareorep ma nā pūnaewele Natural Killer (NK) a me nā loiloi o nā laʻana koko mai nā mea maʻi me nā metastases ate colorectal i lawe ʻia ma mua a ma hope o ka mālama ʻana me ka pelareorep. Ua hōʻike nā hopena i ka pelareorep lapaʻau i alakaʻi ʻia i ka hoʻāla ʻana o nā pūnaewele NK, i ʻike ʻia e pepehi pololei i nā maʻi maʻi maʻi ʻoiai e hoʻoulu ana i ka adaptive anti-tumor immunity. Ua ʻike ʻia nā hopena maikaʻi o ka pelareorep ma nā laʻana maʻi a me ka in vitro a ua hoʻopili ʻia e ke ʻano 1 interferon (IFN-1) hōʻailona, ​​kahi ala nui e pili ana i ka immunoregulation a me ka ʻike ʻana o ka cell tumor.

"Ke hōʻike hou nei kēia mau hopena koʻikoʻi i ke ʻano o ka hana immunologic innate a adaptive o ka pelareorep, a hauʻoli mākou i ka paʻi ʻia ʻana o ia mau mea i loko o kahi puke moʻolelo hanohano, loiloi ʻia e nā hoa," wahi a Kauka Matt Coffey, Pelekikena a Luna Nui o Oncolytics Biotech a hoa kākau o ka pepa. "I ka nānā ʻana i kēia mau ʻike, me ka ʻikepili mua e hōʻike ana i ka hiki i ka pelareorep ke hoʻōla i nā cell T i ka wā e hoʻolaha ana i kā lākou infiltration i loko o nā ʻōpū, ʻike mākou i ka pelareorep e hāʻawi ana i kahi pane anti-cancer immune paʻa i alakaʻi ʻia e nā ʻōnaehana kūlohelohe kūlohelohe a adaptive. Ke nānā nei i mua, e hoʻomau mākou i ka hoʻohana ʻana i nā hopena immunotherapeutic o pelareorep ke hoʻomau nei mākou i kona hoʻomohala ʻana ma ke ʻano he ʻenehana hiki i ka ʻāpana ākea o nā ʻāpana immunotherapeutic i ka umauma umauma a me nā hōʻailona oncologic me nā pono kiʻekiʻe ʻole.

ʻO nā laʻana maʻi i loiloi ʻia ma ka paʻi ʻana mai kahi haʻawina hoʻomaʻamaʻa puka makani-o-manawa kūpono e loiloi ana i ka pelareorep i nā maʻi maʻi maʻi colorectal me nā metastases ate. Ua loaʻa i nā poʻe maʻi ma waena o hoʻokahi a me ʻelima mau kaila o ka pelareorep ma mua o ka hoʻolālā ʻana i hoʻolālā ʻia e wehe i nā metastases. Lawe ʻia nā laʻana koko ma mua a ma nā manawa he nui ma hope o ka mālama ʻana i ka pelareorep. Loaʻa nā kikoʻī hou aku o ka hoʻokolokolo, a me nā hopena i hōʻike mua ʻia, ma nā puke i loiloi ʻia e nā hoa.