Moho Laau Laau Hou no ka Carbapenem-Resistant Bacterial Infections

Ua hoʻolaha aku nei ʻo Sumitomo Dainippon Pharma Co., Ltd., i ka hoʻomaka ʻana o kahi noiʻi pae 1 ma US ma kahi moho lāʻau hou ("KSP-1007") no nā maʻi bacterial-resistant carbapenem. . ʻO ka hoʻomaka ʻana he hopena ia o kahi papahana noiʻi hui ma waena o Sumitomo Dainippon Pharma a me ka Kitasato Institute ma Iapana. Ke alakaʻi nei ʻo Sumitvant i ka papahana o ka hui i ka US e ʻimi ana i nā maʻi urinary paʻakikī a me nā maʻi intra-abdominal.            

"Aia kahi pono lapaʻau kūpono ʻole no ka mālama pono ʻana i nā maʻi paʻakikī a puni ka honua," wahi a Myrtle Potter, Luna Nui o Sumitvant. "ʻO ka hoʻomohala ʻana i nā lāʻau lapaʻau antibacterial hou ʻaʻole i koʻikoʻi a koʻikoʻi paha. Ke manaʻoʻiʻo nei au hiki i kēia moho lāʻau lapaʻau ke lilo i koho lapaʻau maikaʻi e kūʻē i nā maʻi bacterial kūʻē i ka carbapenem e hoʻopilikia i nā poʻe he nui ma US a ma waho.

ʻO nā maʻi maʻi urinary kekahi o nā kumu maʻamau o ka sepsis. ʻO nā maʻi paʻakikī ka mea i ʻoi aku ka nui o ka pilikia o ka hiki ʻole o ka mālama ʻana a koi pinepine i nā papa antibiotic lōʻihi. ʻO nā maʻi paʻakikī i loko o ka ʻōpū he mau maʻi ia e hoʻonui i ka paia o kahi viscus hollow o ka kumu i loko o ka ʻōpū o ka ʻōpū ʻoiai e pili ana me kahi abscess a peritonitis.

"Uaʻikeʻia mai kaʻikepili nonclinical ka KSP-1007 ākea a ikaika i ka β-lactamases,ʻo ia nā enzymes i hanaʻia e ka bacteria e hiki ai ke hoʻohaʻahaʻa i nā lāʻau'alopelo carbapenem," wahi a Salomon Azoulay, MD Chief Medical Officer a me ke poʻo o ka Research & Development ma Sumitvant, nona ka hui i alakaʻi i ka hoʻolālā a me ka hoʻokō ʻana i ka haʻawina ʻo 1 ma US "Ke aʻo nei mākou i ka KSP-1007 i hui pū ʻia me ka meropenem hydrate, kahi lāʻau lapaʻau carbapenem, ua hoʻohana nui ʻia e mālama i nā maʻi Gram (-), e hoʻomaikaʻi i ka pono i ka paʻakikī. nā maʻi mimi a me nā maʻi intra-abdominal.

ʻO ka hoʻomohala ʻana i nā antibiotika hou he pilikia koʻikoʻi honua. ʻO ka puka ʻana a me ka hoʻolaha ʻana o ka bacteria antimicrobial resistant (AMR), ka mea kū i ka lāʻau antibiotic, ke ulu nei ka pilikia a me ka hopohopo. Manaʻo ka World Bank he 700,000 poʻe e make ana i nā maʻi bacteria AMR i kēlā me kēia makahiki. Ma muli o ka piʻi ʻana o ka hoʻohana ʻana i nā lāʻau ʻokoʻa e pili ana i ka COVID-1, aia ka hopohopo e hoʻolaha hou aku ka maʻi maʻi antimicrobial.

Ua kūpaʻa ʻo Sumitomo a me Sumitomo Dainippon Pharma i ka ʻimi ʻana i nā koho lapaʻau hou no nā lāʻau lapaʻau paʻakikī loa a me nā kūlana a puni ka honua. ʻO ka hoʻomohala ʻana i nā lāʻau lapaʻau antibacterial hou kekahi wahi o ka nānā ʻana i nā mea noiʻi o nā hui.