Mea Hou no ka Therapeutic Effective Against Aggressive Cancer Cells

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Ua hoʻolaha ʻo Hoth Therapeutics, Inc. i kēia lā i kahi hoʻomohala hoʻomohala no kāna ʻano lapaʻau maʻi maʻi maʻi hou, HT-KIT. ʻO ke ala hou o Hoth, e hoʻohana ana i kahi oligonucleotide antisense chemically-stable e hoʻopaʻa i ka proto-oncogene KIT ma o ka hoʻololi ʻana i nā transcripts KIT mRNA, hiki ke loaʻa i ka KIT-target therapeutic wale nō, a i ʻole i hui pū ʻia me nā mea hana e kuhikuhi ana i ka hōʻailona KIT, i ka mālama ʻana ʻO nā maʻiʻino pili i ka KIT.

Ma o ka ʻaelike noiʻi ʻepekema i kākoʻo ʻia me North Carolina State University, ua hoʻohana ka hui i ka HT-KIT mRNA frame-shifting approach ma mast cell leukemia cell in vitro a ʻike ʻia ua hōʻemi ʻia ka hōʻike protein KIT, ka hōʻailona a me ka hana. ʻO ka lapaʻau ʻana me HT-KIT ka mea i pale i ka ulu ʻana o ka maʻi maʻi a hoʻoulu i ka make cell ma mua o 72 mau hola. Ma ke ʻano ʻiole mast cell mast cell leukemia i hoʻohālikelike ʻia, ua hoʻemi ʻia ka ulu ʻana a me ka infiltration o nā kino ʻē aʻe a ua hoʻonui ʻia ka make ʻana o ka cell tumor i ka wā i hoʻokomo ai ʻo HT-KIT frameshifted c-KIT mRNA.

Ua waiho ʻo Hoth i nā noi patent e pale i kēia IP a puni ka honua. 

"Me kā mākou lāʻau lapaʻau HT-KIT, ke kāʻili nei mākou i kahi hōʻailona maʻi maʻi nui e pili ana i nā maʻi maʻi ʻino he nui, e like me ka systemic mastocytosis, mast cell leukemia, gastrointestinal stromal tumors and acute myeloid leukemia. ʻO kā mākou ala e pale aku ai i nā pitfalls e pili ana i ka hoʻololi ʻana o KIT ma ka huli ʻana i ka mRNA. Ke holo nei kā mākou mau haʻawina preclinical aʻe a hauʻoli mākou e hoʻohana i nā hopena no kā mākou hui Pre-IND i hoʻolālā ʻia me FDA ma hope o kēia makahiki, "wahi a Robb Knie, Luna Nui o Hoth.

Ua koho ʻia ʻo HT-KIT, kahi hui molekala hou ma ke ʻano he Orphan Drug no ka mālama ʻana i ka mastocytosis ma mua o 2022. Ua hoʻopau maikaʻi ʻo HT-KIT Hoth i ka hiki ke hana i ka mea lāʻau HT-KIT me ka hui pū me WuXi STA.

Hāʻawi ʻia ʻo FDA Orphan Drug Designation i nā lāʻau lapaʻau noiʻi e hoʻoponopono ana i nā maʻi olakino a i ʻole nā ​​kūlana e pili ana i ka liʻiliʻi ma mua o 200,000 poʻe ma ʻAmelika Hui Pū ʻIa. Hāʻawi ke kūlana lāʻau makua ʻole i nā pōmaikaʻi i nā mea hoʻomohala lāʻau, me ke kōkua ʻana i ke kaʻina hana hoʻomohala lāʻau, nā hōʻaiʻē ʻauhau no nā koina lapaʻau, hoʻokuʻu ʻia mai kekahi mau uku FDA a me ʻehiku mau makahiki o ka kūʻai kūʻai ʻana ma hope o ka ʻae ʻia.

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Linda Hohnholz

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