ʻO ka iwi maha a me nā maʻi hui: wehewehe ka ʻepekema

ʻO ka iwi maha a me nā maʻi hui: wehewehe ka ʻepekema
iwi

Wehewehe nā kānaka ʻepekema i ka hana a kekahi protein i ka hanauna o nā hunaola koʻikoʻi i ka mālama ʻana i ka iwi

ʻO nā iwi maha a me nā maʻi hui, e like me ka osteoporosis a me ka rheumatoid arthritis, e hoʻopili i miliona o ka poʻe ma ka honua holoʻokoʻa, ʻo ka poʻe ʻelemākule, e hoʻohaʻahaʻa i ko lākou ola. ʻO kahi mea nui i loko o kēia mau maʻi ʻelua ka hana nui o nā hunaola hoʻoheheʻe iwi i kapa ʻia he osteoclasts. Hoʻokumu ʻia ka osteoclasts ma o ka hoʻokaʻawale ʻana mai kekahi ʻano o ke keʻena pale pale i kapa ʻia he macrophage, a ma hope iho ua loaʻa iā lākou kā lākou kuleana hou i ka mālama ʻana i nā iwi a me nā hono: ka haki ʻana i nā iwi o ka iwi e ʻae ai i nā osteoblast — kekahi ʻano o nā pūnaewele — e hoʻoponopono a hoʻoponopono hou i ka ʻōiwi .

ʻO ka laulā, ʻelua mau hana intracellular e pili ana i kēia ʻokoʻa: ʻo ka mea mua, ka palapala - kahi i hoʻokumu ʻia ai kahi ʻelele RNA (mRNA) mai ka ʻike kūpuna i loko o ka DNA - a laila, ka unuhi - kahi i decode ʻia ai ka ʻike i loko o ka mRNA e hana i nā protein i hana i nā hana kikoʻī i loko o ke keʻena. Mai ka loaʻa ʻana o ke kuleana o kahi protein i kapa ʻia ʻo RANKL i ka hoʻokumu ʻana osteoclast, ua hoʻoholo nā ʻepekema i kahi ʻāpana nui o ka puzzle o nā ala hōʻailona cell a me nā kikowaena transcription e hoʻoponopono i ka hanauna osteoclast. Eia nō naʻe, mau ka hoʻomaopopo ʻia ʻana o ke kaʻina hana pūnaewele post-transcription.

I kēia manawa, i loko o kahi noiʻi hou i paʻi ʻia ma Biochemical a me Biophysical Research Communities, nā mea ʻepekema ma Tokyo University of Science, Iapana, i wehe i ke kuleana o kahi protein i kapa ʻia ʻo Cpeb4 i kēia kaʻina paʻakikī. ʻO Cpeb4 kahi ʻāpana o ka "cytoplasmic polyadenylation element binding (CPEB)" ʻohana o nā protein, kahi e hoʻopili ai iā RNA a hoʻoponopono i ka hoʻonā translational a me ka repression, a me nā ʻano "splicing splicing" e hoʻohua i nā ʻano protein. ʻO Dr Tadayoshi Hayata, ka mea nāna i alakaʻi i ke aʻo ʻana, wehewehe: "Hoʻopili ʻia nā protein CPEB i loko o nā hanana olaola like ʻole a me nā maʻi, e like me ka autism, ka maʻi ʻaʻai, a me ka hoʻokaʻawale ʻana o ke koko ʻulaʻula. Eia nō naʻe, ʻaʻole maopopo leʻa kā lākou hana ma ka hoʻokaʻawale ʻana osteoclast. No laila, ua alakaʻi mākou i kahi papa o nā hoʻokolohua e hōʻike i kahi protein mai kēia ʻohana, Cpeb4, me ka hoʻohana ʻana i nā moʻomeheu o ka iole. "

I loko o nā hoʻokolohua moʻomeheu ʻē aʻe i mālama ʻia, hoʻoulu ʻia nā macrophages iole me RANKL e hoʻoulu ai i ka hoʻokaʻawale ʻana o ka osteoclast a ua nānā ʻia ka ulu ʻana o ka moʻomeheu. ʻO ka mea mua, ua ʻike nā ʻepekema i ka hōʻike moʻokūʻauhau Cpeb4, a no laila ka nui o ka protein Cpeb4, hoʻonui ʻia i ka hoʻokaʻawale ʻana o ka osteoclast. A laila, ma o ka microscopy immunofluorescence, ʻike lākou i nā loli i kahi o Cpeb4 ma loko o nā hunaola. Ua ʻike lākou i ka neʻe ʻana o Cpeb4 mai ka cytoplasm a i loko o nā nuclei, ʻoiai ke hōʻike nei i nā kinona kikoʻī (ʻo nā osteoclasts e hui pū a hana i nā hunaola me nā mea nui he nui). Hōʻike kēia i ka hana o Cpeb4 e pili ana me ka hoʻokaʻawale ʻana osteoclast e lawe ʻia i loko o ka nuclei.

E hoʻomaopopo pehea e hoʻonāukiuki ai ʻo RANKL i kēia Cpeb4 relocalization, ua "kāohi" a ʻepekema paha nā ʻepekema i kekahi o nā protein i lilo i "downstream" i nā ala hōʻailona intracellular i hoʻoulu ʻia e ka stimulate. Ua ʻike lākou i ʻelua ala i pono no ke kaʻina hana. Eia nō naʻe, koi ʻia nā hoʻokolohua hou aku e aʻo piha e pili ana i ke kaʻina o nā hanana i kū a me nā protein āpau i pili.

ʻO ka mea hope loa, ua hōʻike ʻo Dr Hayata a me kāna hui e pono maoli ʻo Cpeb4 no ka hoʻokumu ʻana i ka osteoclast me ka hoʻohana ʻana i nā moʻomeheu macrophage kahi i pau ai ʻo Cpeb4. ʻAʻole i loaʻa i nā pūnaewele i kēia mau moʻomeheu ka ʻokoʻa hou aʻe e lilo i osteoclasts.

Lawe pū ʻia, nā hopena he pōhaku keʻehi i ka hoʻomaopopo ʻana i nā ʻano o ke kelepona e pili ana i ka hoʻokumu osteoclast. Ua ʻōlelo ʻo Dr Hayata: "Ke hoʻomālamalama nei kā mākou noi i ke kuleana nui o ka protein RNA-binding protein Cpeb4 ma ke ʻano he" influencer "maikaʻi o ka hoʻokaʻawale ʻana osteoclast. Hāʻawi kēia iā mākou i ka ʻike ʻoi aku o ke kūlana pathological o ka iwi a me nā maʻi ami a hiki ke kōkua i ka hoʻomohala ʻana i nā hoʻolālā therapeutic no nā maʻi nui e like me ka osteoporosis a me ka rheumatoid arthritis. " Lana ka manaʻo, ʻo ka pae hohonu o ka ʻike o ka hanauna osteoclast i kōkua ʻia e kēia noi ʻana e unuhi i ka maikaʻi o ke ola no nā poʻe e noho nei me nā iwi ʻeha a me nā hui pū.

E pili ana i ke Kulanui ʻEpekema o Tokyo
ʻO Ke Kulanui ʻEpekema ʻo Tokyo (TUS) kahi kula kaulana a kaulana hoʻi, a ʻo ke kulanui noiʻi pilikino pilikino kūikawā nui loa ma Iapana, me ʻehā mau pā kula ma ke kikowaena o Tokyo a me nā wahi e pili ana a me Hokkaido. Hoʻokumu ʻia i ka makahiki 1881, ua kōkua mau ke kulanui i ko Iapana ulu ʻana i ka ʻepekema ma o ka hoʻokomo ʻana i ke aloha no ka ʻepekema i nā kānaka noiʻi, nā loea, a me nā mea aʻo.
Me ka nuʻukia o "E hana i ka ʻepekema a me ka ʻenehana no ka ulu lōkahi o ke kūlohelohe, nā kānaka, a me ke kaiāulu", ua hana ʻo TUS i kahi ākea o ka noiʻi mai ke kumumanaʻo i ka ʻepekema noi. Ua ʻapo ʻo TUS i kahi ala multidisciplinary e noiʻi ai a mālama ʻia i ke aʻo ikaika ʻana i kekahi o nā hana nui o kēia lā. ʻO TUS kahi meritocracy kahi e ʻike ʻia ai a mālama ʻia ai ka ʻoi loa o ka ʻepekema. ʻO ia wale nō kahi kulanui pilikino i Iapana i hana i kahi Nobel Prize lanakila a ʻo ke kulanui pilikino ʻĀkia wale nō ma Asia e hoʻokumu i nā mea lanakila Nobel ma loko o ka ʻepekema kūlohelohe.

E pili ana i ka polopeka ʻo Tadayoshi Hayata mai ke Kula Nui ʻEpekema ʻo Tokyo
Mai ka 2018, ʻo Dr Tadayoshi Hayata he Kumu Polopeka a me kahi mea noiʻi nui ma ke Keʻena ʻo Molecular Pharmacology, Kumu Kula ʻEpekema ʻOihana lāʻau, ma ke Kula Nui ʻEpekema ʻo Tokyo. ʻO kāna keʻena hoʻokolohua ke nānā nei i ka metabolism o ka iwi, ka hoʻokaʻawale ʻana o ka pūnaewele, ka lāʻauola lāʻau, a me nā māla like e hoʻomaopopo i ke ʻano o ka iwi a me nā maʻi hui a loaʻa i nā pahuhopu therapeutic. Pili ʻo Dr Hayata me kekahi mau Societies Iapana a me ka ʻAmelika Hui Pū ʻIa no ka ʻImi Bone a me ka Mineral. Ua paʻiʻo ia ma luna o 50 mau ʻatikala a hāʻawi ʻia ma mua o 150 mau hōʻike ma nā ʻaha kūkā ʻāpana. Eia hou, ʻo kāna noiʻi e pili ana i ka osteoporosis ua hana ʻia i nā nūpepa Iapana i nā manawa he nui.

ʻIke kālā
Ua kākoʻo ʻia kēia noiʻi ʻana e JSPS KAKENHI [hāʻawi helu 18K09053]; Nanken-Kyoten, TMDU (2019); ka Nakatomi Foundation; Kākoʻo noiʻi Astellas; Hāʻawi Pfizer Academic; ʻO Daiichi-Sankyo Hoʻolālā Kālā; Hāʻawi Haʻawina Kula ʻo Teijin Pharma; ʻO Eli Lilly Iapana Haʻawina Hoʻolālā; Hāʻawi ʻo Otsuka pharmaceutical Academic Contribution; Hāʻawi Kula Shionogi; Hāʻawi Chugai ʻOihana Haumana Kula.

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