ʻO ka ʻike hou ʻana o ka pale i ka maʻi maʻi maʻi pancreatic ʻo kā mākou mau pūnaewele ponoʻī

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Ma ke alo o nā ʻōpū pancreatic, hoʻohiolo kekahi mau cell immune i nā protein structural i loko o nā molekala e hoʻoulu ai i ke kūkulu ʻana i nā ʻiʻo paʻa, kahi mea pale i ʻike ʻia i ka lāʻau lapaʻau, ʻike ʻia kahi noiʻi hou. 

Alakaʻi ʻia e nā mea noiʻi mai NYU Grossman School of Medicine, ʻo ke aʻo ʻana e hoʻopuni ana i ka meshwork protein paʻa e kākoʻo ana i nā kino a kōkua i ke kūkulu hou ʻana i nā ʻiʻo i hōʻino ʻia. ʻO nā fiber protein collagen, ka mea nui o ka mesh, e wāwahi mau ʻia a hoʻololi ʻia e mālama i ka ikaika tensile, a ma ke ʻano o ke kaʻina hana hoʻōla ʻeha.

Ua hōʻike ʻia nā haʻawina i hala e pili ana nā cell immune i kapa ʻia ʻo macrophages i kahi kaʻina i kapa ʻia ʻo desmoplasia, ka mea i hoʻokumu ʻia e ka huli ʻana a me ka nui o ka waiho ʻana o ka collagen e hoʻokaʻawale i nā maʻi maʻi pancreatic. I loko o kēia kaiapuni, ʻike ʻia nā macrophages e hoʻopau a wāwahi i ka collagen ma o ka hana a kahi protein i kapa ʻia ʻo ka mannose receptor (MRC1).

Ke paʻi ʻia nei ma ka pūnaewele ʻApelila 4 i ka Proceedings of the National Academies of Sciences, ua ʻike ka haʻawina i kēia manawa ua hoʻonui ka collagen degraded i ka nui o arginine, he amino acid i hoʻohana ʻia e ka enzyme nitric oxide synthase (iNOS) e hana i nā pūhui i kapa ʻia nā ʻano nitrogen reactive. (RNS). ʻO kēia, ka mea i hoʻokumu i nā pūnaewele stellate kākoʻo e kūkulu i nā meshes e pili ana i ka collagen a puni nā ʻōpū, wahi a nā mea kākau noiʻi.

"Ua hōʻike kā mākou mau hopena i ke ʻano o ka papahana ʻana o nā maʻi pancreatic macrophages e kōkua i ke kūkulu ʻana i nā pale fibrotic," wahi a ka mea kākau noiʻi mua ʻo Madeleine LaRue, PhD. I ka manawa o ke aʻo ʻana, he haumāna puka puka ʻo LaRue ma ke keʻena o ka mea kākau noiʻi kiʻekiʻe ʻo Dafna Bar-Sagi, PhD, ka S. Farber Professor of Biochemistry and Molecular Pharmacology a me Hope Dean for Science ma NYU Langone Health. "Hiki ke hoʻohana ʻia kēia molecular framework e pale aku i nā loli pro-cancer i loko o nā ʻiʻo e pili ana i nā ʻōpū," wahi a LaRue. 

ʻO ka maʻi maʻi pancreatic ke kolu o ke kumu nui o ka make e pili ana i ka maʻi kanesa ma ʻAmelika Hui Pū ʻIa, me ka helu ola ʻelima makahiki o 10%. He paʻakikī ka mālama ʻana i ka maʻi ʻaʻai pancreatic ma muli o ka nui o nā ʻiʻo fibrotic a puni nā ʻōpū. ʻAʻole wale kēia pūnaewele e poloka i ke komo ʻana e nā lāʻau lapaʻau, akā hoʻolaha pū kekahi i ka ulu ulu ʻana.

No ka noiʻi o kēia manawa, ua hōʻike nā hoʻokolohua i ulu ʻia nā macrophages i nā kīʻaha o nā meaʻai (nā moʻomeheu), a ua hoʻololi ʻia i loko o kā lākou hoʻonohonoho hoʻomanawanui ʻana i ka maʻi kanesa (M2), ua wāwahi ʻoi aku ka nui o ka collagen ma mua o nā macrophages e hoʻouka i nā maʻi kanesa (M1). Eia hou, ua hōʻoia ka hui me kahi ʻano o nā hoʻāʻo e loaʻa i ka M2 macrophages nā pae kiʻekiʻe o nā enzyme e hoʻoulu ai i ka RNS, e like me iNOS.

No ka hōʻoia ʻana i kēia mau ʻike i nā ʻiole ola, ua hoʻokomo ka hui i nā pūnaewele stellate i "hānai mua ʻia" me ka collage, a i mālama ʻia i loko o kahi kūlana hānai ʻole, i loko o nā ʻaoʻao o nā holoholona aʻo me nā pūnaewele maʻi maʻi pancreatic. Ua ʻike ka hui i ka piʻi ʻana o ka 100 pakeneka o ka nui o ka intra-tumoral collagen fibers i loko o nā ʻōpū i loaʻa mai nā maʻi maʻi maʻi i hoʻopili pū ʻia me nā cell stellate i mālama mua ʻia me ka collagen.

ʻO ka mea nui, ua hōʻike ʻia ka noiʻi no ka manawa mua i ka macrophages kokoke i ka pancreatic cancer cells, ʻaʻole wale e lawe i loko a wāwahi i nā collagen ma ke ʻano he ʻāpana o ka scavenging no nā protein e hānai i ka ulu kūlohelohe, akā ua hoʻololi ʻia hoʻi e ka scavenging, e like me kā lākou ʻōnaehana hoʻoponopono ikehu. (metabolism) ua hoʻopili hou ʻia a me nā hōʻailona no ke kūkulu ʻana i ka fibrotic.

"Ua wehe kā mākou hui i kahi ʻano hana e hoʻopili ai i ka huli ʻana o ka collagen i ke kūkulu ʻana i kahi kaiapuni kūpaʻa e pili ana i nā ʻōpū pancreatic," wahi a Bar-Sagi. "ʻOiai ʻo kēia kaiapuni paʻa kahi kumu nui e make ai ka maʻi maʻi pancreatic, ʻoi aku ka maikaʻi o ka hoʻomaopopo ʻana i nā loulou ma waena o ka scavenging protein a me ke kūkulu ʻana i nā pale pale e pono ai ka hoʻomaikaʻi ʻana i ka mālama ʻana i kēia maʻi ʻino."

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Linda Hohnholz

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