Ua ʻike ʻia ka loulou hou ma waena o nā maʻi maʻi maʻi maʻi Alzheimer

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ʻO ke aʻo ʻana i nā kumu paʻakikī o ka maʻi Alzheimer, a pehea e mālama ai a pale aku ai i kēia maʻi, ua like ia me ka hoʻoponopono ʻana i kahi puʻupuʻu he nui, me ka poʻe ʻepekema e hoʻoponopono i kahi ʻāpana liʻiliʻi, ʻaʻole maopopo i ke ʻano o ke kiʻi nui. I kēia manawa, ua hoʻoholo ka poʻe noiʻi ma Gladstone Institutes pehea e hui pū ai ka lima o nā ʻāpana puzzle i pili ʻole ʻia.

I loko o kahi noiʻi i paʻi ʻia ma ka puke pai iScience, hōʻike ka hui i ka hana epileptic maʻalahi e hoʻoikaika i ka ʻeha o ka lolo ma nā ʻano ʻiole e hoʻohālikelike ana i nā ʻano koʻikoʻi o ka maʻi o Alzheimer. Hōʻike ka poʻe ʻepekema he nui nā mea pāʻani i ʻike ʻia i ka maʻi Alzheimer i kūpono i kēia loulou hoihoi ma waena o ka ʻōnaehana nerve a me ka ʻōnaehana pale, e komo pū ana me ka protein tau, pinepine kuhi hewa ʻia a hōʻuluʻulu ʻia i loko o nā lolo maʻi, a me TREM2, kahi kumu pilikia genetic no ka maʻi.

"ʻO kā mākou mau ʻike e hōʻike ana i nā ala e pale ai a hoʻohuli i nā mea ʻino e pili ana iā Alzheimer i nā ʻoihana lolo a me nā hana immune," wahi a Lennart Mucke, MD, ka luna o ka Gladstone Institute of Neurological Disease a me kahi mea kākau kiʻekiʻe o ka noiʻi hou. "Hiki i kēia mau hana ke hōʻemi i nā hōʻailona maʻi a hiki ke kōkua i ka hoʻololi ʻana i ke ʻano o ka maʻi."

Hoʻohui i ka hana maʻi epileptic a me ka ʻā o ka lolo

Ua ʻike ka poʻe ʻepekema no kekahi manawa e pili ana ka maʻi Alzheimer me ka mumū mau i ka lolo. ʻO kahi mea hoʻokele o kēia ʻāʻī e ʻike ʻia ʻo ia ka hōʻiliʻili ʻana o nā protein amyloid ma ke ʻano o nā "plaques," kahi hōʻailona neuropathological o ka maʻi.

I loko o ka noiʻi hou, ua ʻike ka poʻe noiʻi i ka hana epileptic non-convulsive ma ke ʻano he mea hoʻokele koʻikoʻi o ka ʻeha o ka lolo maʻi i loko o kahi kiʻi ʻiole pili i ka Alzheimer. ʻO kēia ʻano hana maʻalahi o ka epileptic i loaʻa i ka hapa nui o ka poʻe me ka maʻi Alzheimer a hiki ke lilo i mea wānana no ka emi ʻana o ka cognitive wikiwiki i nā maʻi.

"ʻO kahi ala e hiki ai i kēia hana epileptic subclinical ke hoʻolalelale i ka emi ʻana o ka cognitive ma o ka hoʻoulu ʻana i ka ʻeha o ka lolo," wahi a Melanie Das, PhD, he kanaka ʻepekema ma ka hui ʻo Mucke a alakaʻi i ka mea kākau o ka pepa. "Ua hauʻoli mākou i ka loaʻa ʻana o ʻelua mau mea lapaʻau i kāohi i ka hana epileptic a me ka ʻeha o ka lolo."

Ma ke ʻano ʻiole, ua pale nā ​​ʻepekema i nā mea ʻino ʻelua me ka hoʻohana ʻana i ka ʻenekinia genetic e hoʻopau i ka protein tau, ka mea e hoʻoikaika ai i ka hyperexcitability neuronal (ke puhi ʻana i nā neurons he nui i ka manawa like). Ua hiki iā lākou ke hoʻohuli i nā hoʻololi i ka neural network a me nā cell immune, ma ka liʻiliʻi loa, ma ka mālama ʻana i nā ʻiole me ka anti-epileptic drug levetiracetam.

ʻO kahi hoʻokolohua hoʻokolohua hou o levetiracetam i puka mai i ka hana mua a Mucke i hōʻike ʻia i nā pōmaikaʻi cognitive i nā poʻe maʻi me ka maʻi o ka maʻi a me ka hana epileptic subclinical, a ua hoʻomohala ʻia nā therapeutics tau-hoʻohaʻahaʻa, e kūkulu pū ana hoʻi i ka noiʻi ʻana ma ka lab o Mucke. Ua hōʻoia hou ka haʻawina hou i ka hoʻohiki ʻana i kēia mau lāʻau lapaʻau no ka poʻe i ka wā mua o ka maʻi o Alzheimer.

ʻO ka hana hou o kahi Gene Risk o Alzheimer

ʻAʻole like ka hū; hiki iā ia ke hoʻokuke i ka maʻi, e like me ke ʻano o ka maʻi rheumatoid arthritis, a i ʻole hiki ke kōkua i ke kino e ho'ōla, no ka laʻana, ma hope o ke ʻoki ʻana.

"He mea nui e hoʻokaʻawale i ke kumu o ka maʻi o Alzheimer i ka ʻeha nui loa, ka maikaʻi ʻole o ka ʻeha maikaʻi, a i ʻole nā ​​​​mea ʻelua," wahi a Mucke, ʻo ia hoʻi ʻo Joseph B. Martin Distinguished Professor of Neuroscience a me ke kaukaʻi neurology ma UC San Francisco. "ʻO ka nānā ʻana i ka hoʻōla ʻana o nā cell inflammatory i ka lolo ʻaʻole e haʻi koke iā ʻoe inā maikaʻi a maikaʻi ʻole paha ka hoʻōla ʻana, no laila ua hoʻoholo mākou e noiʻi hou aku."

Ua ʻike ʻo Mucke a me kāna mau hoa hana, i ka wā i hōʻemi ai lākou i ka hana epileptic i ka lolo ʻiole, ʻo kekahi o nā mea inflammatory i hoʻopilikia nui ʻia ʻo TREM2, i hana ʻia e microglia, nā cell immune noho o ka lolo. ʻO ka poʻe me nā ʻano genetic o TREM2 he ʻelua a ʻehā paha manawa e ulu ai ka maʻi o Alzheimer ma mua o ka poʻe me ka TREM2 maʻamau, akā ke hoʻāʻo nei ka poʻe ʻepekema e wehewehe i nā kuleana kūpono a kēia mole i ke olakino a me ka maʻi.

Ua hōʻike mua ka poʻe ʻepekema ua hoʻonui ʻia ka TREM2 i loko o ka lolo o nā ʻiole me nā pā amyloid, akā hoʻemi ʻia ma hope o ka hoʻopau ʻana i kā lākou hana epileptic. No ka ʻike ʻana i ke kumu, ua nānā lākou inā pili ʻo TREM2 i ka maʻalahi o nā ʻiole i nā haʻahaʻa haʻahaʻa o kahi lāʻau lapaʻau e hiki ai ke hana i ka hana epileptic. ʻO nā ʻiole me nā pae haʻahaʻa o TREM2 i hōʻike i ka hana epileptic i ka pane ʻana i kēia lāʻau lapaʻau ma mua o nā ʻiole me nā pae TREM2 maʻamau, e manaʻo ana e kōkua ʻo TREM2 i ka microglia e kāohi i nā hana neuronal abnormal.

"ʻO kēia hana a TREM2 he mea i manaʻo ʻole ʻia a manaʻo ʻia e hoʻonui ʻia nā kiʻekiʻe o TREM2 i loko o ka lolo e lawelawe maoli i kahi kumu pono," wahi a Das. "Ua aʻo mua ʻia ʻo TREM2 e pili ana i nā hōʻailona pathological o ka maʻi o Alzheimer e like me nā plaques a me nā tangles. Maanei, ua ʻike mākou he kuleana ko kēia mole i ka hoʻoponopono ʻana i nā hana neural network.

"ʻO nā ʻano genetic o TREM2 e hoʻonui ai i ka pilikia no ka maʻi o Alzheimer e hōʻino i kāna hana," hoʻohui ʻo Mucke. "Inā ʻaʻole hana maikaʻi ʻo TREM2, ʻoi aku ka paʻakikī o nā cell immune e kāohi i ka hyperexcitability neuronal, ʻo ia hoʻi ke kōkua i ka hoʻomohala ʻana i ka maʻi o Alzheimer a me ka wikiwiki o ka emi ʻana o ka cognitive."

Ke hoʻomohala nei kekahi mau hui lāʻau lapaʻau i nā antibodies a me nā mea hoʻohui ʻē aʻe e hoʻomaikaʻi i ka hana o TREM2, ma mua e hoʻomaikaʻi i ka wehe ʻana i nā pā amyloid. Wahi a Mucke, hiki i kēlā mau lāʻau lapaʻau ke kōkua i ka hoʻopaʻa ʻana i ka hana pūnaewele maʻamau i ka maʻi o Alzheimer a me nā kūlana pili.

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Linda Hohnholz

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