Ka maʻi maʻi koko kamaliʻi: ke kuleana nui o nā meaʻai

Alakaʻi ʻia e nā mea noiʻi ma NYU Langone Health, kāna Keʻena ʻOihana, a me ka Laura a me Isaac Perlmutter Cancer Center, ua hōʻike ʻia ka haʻawina e ʻoi aku ka ikaika o nā genes i ka hoʻohana ʻana i ka valine i loko o nā cell cancerous T ma mua o nā cell T maʻamau.                                                                                                       

ʻO ka pale ʻana i kēia mau genes pili i ka valine ʻaʻole i alakaʻi wale i ka valine i hoʻemi ʻia i loko o nā keʻena T koko maʻi leukemia, akā ua hoʻopaʻa pū ʻia kēia mau ʻōpū mai ka ulu ʻana i ka lab. He 2 pakeneka wale nō o nā pūnaeau T ma'i 'a'ai i ola.

Eia hou, ua manaʻo nā hoʻokolohua e hoʻololi (mutations) i ke code DNA o ka gene NOTCH1, ka mea maʻamau i ʻike ʻia i nā poʻe maʻi e hoʻomohala nei i ka maʻi leukemia, e paipai i ka ulu ʻana o ka maʻi kanesa ma ka hoʻonui ʻana i nā pae valine.

Hoʻopuka ʻia ma ka puke pai Nature online Dec. 22, ua pili ka noiʻi i nā hoʻokolohua i loko o nā pūnaewele leukemia kanaka i ulu i loko o ke keʻena hana a hoʻololi pū ʻia i loko o nā ʻiole a laila hoʻomohala i kēia maʻi kanesa, nona ka kumu i loko o nā keʻokeʻo keʻokeʻo i loko o ka iwi iwi.

Ua hōʻike ʻia nā hoʻokolohua ʻē aʻe i ka hānai ʻana i nā ʻiole leukemic i nā meaʻai haʻahaʻa-valine no ʻekolu pule i hoʻopau i ka ulu ʻana o ka maʻi maʻi. ʻO ka ʻai hoʻi i hoʻemi i ka holo ʻana o nā maʻi maʻi maʻi koko ma ka hapa liʻiliʻi a ma kekahi mau mea i nā pae undetectable. ʻO ka hoʻokaʻawale ʻana, ʻo ka hoʻokomo hou ʻana i ka valine i nā meaʻai i alakaʻi i ka piʻi ʻana o ka maʻi kanesa.

"Ke hōʻoia nei kā mākou noiʻi ʻana ʻo T cell acute lymphoblastic leukemia e hilinaʻi nui ʻia i ka lako o valine a hiki i ka hemahema o valine ke hoʻopaʻa i ka holomua o kēia maʻi kanesa," wahi a ka mea noiʻi alakaʻi alakaʻi ʻo Palaniraja Thandapani, PhD, he hoa postdoctoral ma NYU Grossman School of Medicine and ʻo ia ʻo Perlmutter Cancer Center.

Ua hoʻolālā ka hui noiʻi i ka makahiki aʻe e hoʻāʻo ai inā he mea lapaʻau maikaʻi nā meaʻai haʻahaʻa i nā meaʻai waiwai nui o valine, e like me ka ʻiʻo, ka iʻa, a me nā pīni. Hiki ke loaʻa nā meaʻai haʻahaʻa-valine, wahi a Thandapani, no ka mea, ke hoʻohana ʻia nei lākou no ka mālama ʻana i nā ʻano like ʻole o ka waikawa i loko o ke kino i hoʻopaʻa ʻia i nā maʻi genetic e pili ana i ka metabolism o ka ʻōpū.

Wahi a ka mea noiʻi noiʻi nui ʻo Iannis Aifantis, PhD, ʻo ka hoʻolālā hoʻāʻo e hui pū i ka lāʻau ʻai me ka venetoclax, he lāʻau lapaʻau i ʻae ʻia no ka hoʻohana ʻana ma ʻAmelika no ka hapa nui o nā ʻano leukemia.

He mea nui ka hui ʻana o ka lāʻau, ʻōlelo ʻo ia, no ka mea, ʻaʻole hiki ke hoʻomau ʻia nā mea ʻai i ka wā lōʻihi. ʻO kēia ma muli o ka hiki ke ʻike ʻia no ka pau ʻana o ka ʻiʻo a me ka pōʻino o ka lolo mai ka hemahema o ka valine lōʻihi.

"ʻO kā mākou hoʻokolohua lapaʻau e pili ana i ka hoʻohana ʻana i nā meaʻai haʻahaʻa-valine e hōʻemi i ka nui o nā cell T me ka maʻi leukemia lymphoblastic acute i kahi pae haʻahaʻa loa e hiki ai i nā lāʻau lapaʻau ke hoʻopaʻa pono i ka piʻi ʻana o ka maʻi kanesa," wahi a Aifantis, ka Hermann M. Biggs Professor a me ka noho o ka Keʻena o ka Pathology ma NYU Grossman a me Perlmutter.

Ua ʻōlelo ʻo Aifantis he nui nā poloka kūkulu hale maʻamau, ʻo ia hoʻi nā protein, nucleotides, a me nā momona momona, pono e ulu a laha ka maʻi kanesa. Ma kahi o ka hapalua o nā ʻakika amino ʻē aʻe, ʻoi aku ka nui o ka lysine kiʻekiʻe, ua hoʻopili ʻia i nā maʻi maʻi maʻi, akā ʻaʻole ʻike ʻia ko lākou kuleana pololei. Ua ʻōlelo ʻo ia ua hoʻāʻo ʻia nā hoʻolālā meaʻai wale nō no ka mālama ʻana i ka maʻi kanesa no nā makahiki he nui me nā hōʻike ʻepekema liʻiliʻi o kekahi pono. Ua ʻōlelo ʻo ia e pono ana ka noiʻi hou aʻe, me ka hoʻāʻo hoʻokolohua lapaʻau i hoʻolālā ʻia e ka hui, ma mua o ka hiki ke ʻōlelo ʻia i nā alakaʻi lapaʻau.

Ua manaʻo ka American Cancer Society he ʻoi aku ma mua o 1,500 ʻAmelika, ka hapa nui o nā keiki, make i kēlā me kēia makahiki mai ka T cell acute lymphoblastic leukemia. He 5,000 hou e ʻike hou ʻia. ʻO kēia ʻano maʻi maʻi maʻi e pili ana i ka hapahā o nā maʻi leukemia a pau.

Hāʻawi ʻia ke kākoʻo kālā no ke aʻo ʻana e nā National Institutes of Health nā hāʻawi P30CA016087, P01 CA229086 a me R01 CA228135; ka Leukemia & Lymphoma Society; ʻO ka papahana NYSTEM o New York State Department of Health; a me ka American Association for Cancer Research Incyte Corporation Leukemia Research Fellowship.

He mea aʻoaʻo ʻo Aifantis no Foresite Labs, kahi ʻoihana mālama ola olakino i hoʻokumu ʻia ma Kapalakiko e loaʻa ana nā pono kālā i ka hoʻomohala ʻana i nā maʻi leukemia. ʻO Aristotelis Tsirigos, PhD, ka mea noiʻi noiʻi, lawelawe ma ke ʻano he kākāʻōlelo ʻepekema no Intelligencia.AI ma New York City, kahi hui polokalamu e pili ana i ka aʻo ʻana i ka mīkini i ka hoʻomohala ʻana i ka lāʻau lapaʻau. Ke mālama ʻia nei nā ʻōlelo o kēia mau hoʻonohonoho e like me nā kulekele o NYU Langone.

Ma waho aʻe o Thandapani, ʻo Aifantis a me Tsirigos, ʻo nā mea noiʻi ʻē aʻe o NYU Langone i komo i loko o ke aʻo ʻana he mau mea noiʻi alakaʻi alakaʻi ʻo Andreas Kloetgen; Matthew Witkowski; a me Christina Glytsou; a aʻo pū me nā mea noiʻi ʻo Anna Lee; Eric Wang, Jingjing Wang; Sarah LeBoeuf; Kleopatra Avrampou; a me Thales Papagiannakopoulos.